ROCK2 (rho-associated coiled-coil-containing protein kinase-2) is a protein with numerous functions, and its activity is upregulated in severe inflammatory injury and persistent illness such as diabetes, metabolic syndrome and idiopathic lung fibrosis. Obstructing ROCK2 acts by stopping pro-inflammatory T H17 cells and enhancing regulative T cells to bring back homeostasis. In September the FDA authorized Jakafi (ruxolitinib) for persistent GVHD after failure of a couple of lines of systemic treatment.
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